About

 

Contacts

For guidance in drug discovery
Vince Groppi, Ph.D., vegroppi@umich.edu
Director, Center for the Discovery of New Medicines
Life Sciences Institute

For general information
Ashley Schork, ashlscho@umich.edu
Administrative & Project Coordinator, CDNM
Life Sciences Institute

For media inquiries
Ian Demsky, idemsky@umich.edu
Manager of Communications and Marketing
Life Sciences Institute

CDNM

The Center for Discovery of New Medicines (CDNM) is the translational research/drug discovery center at the University of Michigan. Founded in 2012, it brings together the expertise required to advance projects from idea to clinical proof-of-concept.

CDNM’s collection of early drug discovery expertise includes high throughput screening, chemical genomics, medicinal chemistry, high throughput gene cloning and expression, X-ray crystallography, in vitro assays for ADME and in vivo pharmacokinetics.

The center provides both financial support and project-specific mentorship and consulting for researchers with projects that have therapeutic potential.

Life science researchers at U-M continue advance the understanding of human diseases by doing innovative science to understand the molecular pathology of diseases.  CDNM partners with U-M researchers to help them test the “translational do-ability” of high reward projects derived from this research when data uncovers the potential for a new therapy based on a new understanding of disease.

The mechanism of action includes modulating GPCRs, protein kinases, ion channels, signal transduction pathways, protein misfolding, protein-protein interactions, transcriptional regulation, phenotypic assays, etc.  In all cases, team based-science adds value in developing an executable drug discovery project plan with defined go/no go milestones that has reach through to clinical development.

These translational plans start with the end in mind to address the unmet medical needs in a wide variety of therapeutic areas including oncology, neurodegeneration, psychiatric disorders, cardiovascular disease, metabolic disorders, inflammatory disorders, bacterial and viral infections. 

Executive Committee

James Dalton, Ph.D., Chair
Dean and Professor of Pharmaceutical Sciences

Roger Cone, Ph.D.
Asa Gray Collegiate Professor of the Life Sciences, Mary Sue Coleman Director of the Life Sciences Institute, Research Professor, Life Sciences Institute and Professor of Molecular and Integrative Physiology, Medical School
 
Eric R. Fearon, M.D., Ph.D.
Emanuel N. Maisel Professor of Oncology, Professor, Departments of Internal Medicine, Human Genetics and Pathology, Associate Director for Basic Science and Deputy Director, U-M Comprehensive Cancer Center, Chief, Division of Molecular Medicine & Genetics, Department of Internal Medicine

Lori Isom, Ph.D.
Chair, Department of Pharmacology, Professor of Pharmacology and Professor of Molecular and Integrative Physiology, Medical School
 
Steve Kunkel, Ph.D.
Endowed Professor in Pathology Research, Professor of Pathology, Co-Director, Division of General Pathology and Senior Associate Dean for Research, Medical School

Judith S. Leopold, Ph.D.
Associate Research Professor, Department of Radiology, Translational Oncology Program
 
George Mashour, M.D., Ph.D.
Bert N La Du Professor of Anesthesiology Research, Associate Dean for Clinical and Translational Research, Adjunct Associate Professor of Psychology, Associate Professor of Anesthesiology and Associate Professor of Neurosurgery, Medical School
 
Ed Pagani. Ph.D.
Technology Transfer Associate Director

Charles A. Parkos, M.D., Ph.D.
Carl V. Weller Professor and Chair, Department of Pathology 

James Shayman, M.D.
Agnes C and Frank D McKay Professor, Departments of Pharmacology and Internal Medicine, Medical School
 
David H. Sherman, Ph.D.
Research Professor, Life Sciences Institute, Hans W. Vahlteich Professor of Medicinal Chemistry and Associate Dean for Research and Graduate Education, College of Pharmacy, Professor, Department of Chemistry, Professor, Department of Microbiology and Immunology
 
Shaomeng Wang, Ph.D.
Warner-Lambert/Parke-Davis Professor of Medicine, Professor of Internal Medicine, Professor of Pharmacology, Medical School and Professor of Medicinal Chemistry, College of Pharmacy
 
Max Wicha, M.D., Ph.D.
Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery and Professor of Internal Medicine, Medical School

Funding Organizations

Office of the Provost, College of Pharmacy, Life Sciences Institute, Comprehensive Cancer Center, and the Department of Internal Medicine, Department of Pathology, and Endowment for the Basic Sciences in the U-M Medical School