Funding Opportunities in Drug Discovery
CDNM PILOT & SEED GRANTS FOR ADVANCING DRUG DISCOVERY
Closed until next funding round. Please check back with us after January 1st.
1. NATURE AND PURPOSE OF THIS RFA
The mission of the Center for Discovery of New Medicines (CDNM) at the University of Michigan is to advance projects focused on the discovery and development of innovative new medicines. It will support such projects by providing academic leadership and centralized access to expertise in drug discovery, strong core facilities and infrastructure, and pilot funds.
Funds to facilitate access for UM faculty to Drug Discovery Resources (~$500K per year) have been made available by multiple departments and units. All phases of drug discovery are suitable: screening (virtual and real), structural analysis, compound acquisition and/or optimization, pharmacokinetics, and animal models. Appropriate projects on biologics and drug delivery devices will also be considered.
The bulk of the funds should be used for core facility activities (internal or external) or purchase of critical reagents. up to 10% of the budget may support PI lab supplies or other costs. Personnel, equipment, and travel costs are not permitted. Projects that make heavy use of PI Lab resources (e.g. screens or animal models run in PI lab) should consider MICHR Pilot Proposals or UMCCC HTS pilot grants - see links above).
2. CRITERIA FOR FUNDING
The research must address some aspect of drug discovery. Preference will be given to studies on novel drug targets and/or to projects with good potential for translation. Successful projects will also provide a clear plan for future extramural funding and intellectual property protection.
3. GRANT APPLICATION SUBMISSION AND DECISIONS
Seed Grants – Small grants (<$10,000) will be accepted on a rolling basis with review and decision within ~4-6 weeks.
Pilot Grants - Twice yearly Requests for Application (RFA) are planned for larger studies (up to $50,000). The first deadline is 11:59 PM, February 15, 2013.
For all proposals, support is intended go primarily toward access to core facility services (see listing of available cores at http://cdnm.umich.edu/resources). Advice on the aims and intended use of funds may be obtained by e-mailing the CDNM director (CDNM_director@umich.edu). Grant submissions are online (http://cdnm.umich.edu/grants) as a single PDF document. Seed grants will be reviewed by the CDNM Executive Committee. Accelerator grants will be peer-reviewed and final funding decisions made by the CDNM Executive Committee. Critiques will be made available to investigators after the review process is complete.
All faculty members (instructional and research track) employed by the University of Michigan are eligible to submit applications for this RFA.
In order to permit support of the greatest number of projects, budgets should target one step in the overall drug discovery process and should be limited to the funds required for that step. For example, compound acquisition or virtual screening, can usually be accomplished for <$5,000, PK studies per compound <$10,000, while a Med Chem optimization or High Throughput Screen may require $25,000 or more. The amount awarded will be limited to that required for the proposed research. Support will be for 1 year with rare extensions approved under extenuating circumstances.
The bulk of the funds should be used for core facility activities (internal or external) or purchase of critical reagents. Up to 10% of the budget may support PI lab supplies or other costs. Personnel, equipment, and travel costs are not permitted.
6. FORMAT AND ELEMENTS OF THE PROJECT GRANT APPLICATION
Online submissions only. The application must be uploaded as one file in an Adobe Acrobat (pdf) format through this link.
Required elements of the full application are listed below. The body of the application (sections 4-9) is limited to 5 pages in length. Budget, biosketches and references are not included in this limit.
- Cover Page (Please download this cover page and include with application.)
- Relation to Drug Discovery and/or Translational Research
- Specific aims
- Research plan (for screening grants, feasibility data is required)
- Specific plans for obtaining future external funding
- Intellectual property plan
- Budget and Justification - Budgets should be broken down into three categories:
a. Core facility use or reagent purchase
b. Supplies (unlimited for core use; up to 10% of budget for supplies to be used in PI's lab)
c. Other (justify)
9. Intellectual property plan
10. Literature Citations
11. Biosketches and Other Support Pages for Principal Investigator(s) and key personnel using the NIH-format (Core lab personnel biosketches not required)
The CDNM Director and/or Executive Committee will perform an initial review of all submitted grant applications to ensure alignment with the overall strategic goals of the CDNM. Seed grant reviews will be done by the Executive Committee and designees. For Accelerator Grants, the Executive Committee will recruit 2-3 appropriate individuals from inside and/or outside the UM system to evaluate the scientific merit of the proposals (via written critique). If proprietary information (i.e. novel structures) is included in the proposal, please indicate that on the cover sheet to ensure IP protection. Reviewers will score the proposal (via e-mail communications) on a 1–5 scale. The written critiques serve as feedback for the applicants, with reviewers’ names removed. The Executive Committee will make a final decision on funding according to the criteria and principles discussed above.
All grantees awarded funds agree to submit a final report at the end of the 1-year grant period. They should acknowledge support of the “University of Michigan Center for the Discovery of New Medicines” on any publications resulting from discoveries made in this project. They will also be expected to provide periodic updates on publications, grant submissions, and received grants that derived from this work.
UPLOAD APPLICATION AT https://sitemaker.umich.edu/
If you have questions about the application process, contact Benita Threadgill
Other funding opportunities: