Past Events

2016
 
January 15
“Molecular target identification in kidney disease across disciplines and continents"
Matthias Kretzler, M.D., Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics, U-M Medical School 
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
 
January 22
"Designer Niches for Analyzing Cancer: From Initiation to Metastasis"
Lonnie Shea, Ph.D., William and Valerie Hall Chair and Professor, Department of Biomedical Engineering
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
View the Slides (.pptx)
 
April 8
Denton Hoyer, Ph.D., Director of Chemistry, Yale Center for Molecular Discovery
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

May 6
“Early Clinical Research Takes Patients"
J. Frederick Pritchard, Ph.D., Vice President, Global Drug Development, Celerion
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
 
May 13
“Treating Zika Virus Infection by Targeting ER-associated Quality Control Pathway”
Billy Tsai, Ph.D., Corydon Ford Collegiate Professor and Professor of Cell and Developmental Biology, Medical School
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

May 20
"A novel family of natural products that targets uropathogenic Escherischia coli iron acquisition"
Laura Mike, Ph.D., Research Fellow, Microbiology and Immunology, Medical School
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
 
August 29
“Medicinal Chemistry Education: Issues and Opportunities”
Michael F. Rafferty, Ph.D., Adjunct Professor of Medicinal Chemistry, University of Kansas
Life Sciences Institute Library, Room 3040
9 - 10 a.m.
Host: CDNM and Department of Medicinal Chemistry, College of Pharmacy
 
September 9
"Antibiotic Discovery for Tuberculosis: Returning to a “Golden Target”, RNA Polymerase"
George Garcia, Ph.D., Chair, Department of Medicinal Chemistry
Forum Hall, Palmer Commons
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
 
Monday October 3
"Innovative Therapeutic Approaches Based on Notch Control of Cellular Transdifferentiation"
Chris Seibel, Ph.D, Principal Scientist, Discovery Oncology, Genentech
BSRB, ABC
4-5pm
Hosts: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director and Ivan Maillard, Ph.D., Jeffrey M Leiden Collegiate Professor of the Life Sciences, Research Associate Professor, Life Sciences Institute, Associate Professor of Internal Medicine and Associate Professor of Cell and Developmental Biology, Medical School
 
Thursday October 13
Craig Crews, Ph.D., Professor of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale
Forum Hall, Palmer Commons
9 - 10 a.m.
Hosts: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director and Shaomeng Wang, Ph.D., Warner-Lambert/Parke-Davis Professor of Medicine, Professor of Internal Medicine, Professor of Pharmacology, Medical School and Professor of Medicinal Chemistry, College of Pharmacy
 
October 28
"Fishing, Drug Development, and the Prevention of Acquired Hearing Loss"
Ed Rubel, Ph.D. Professor of Hearing Science, Otalaryngology - Head and Neck surgery, Physiology, and Biophysics, Adjunct Professor of Psychology, University of Washington
Forum Hall, Palmer Commons
9 - 10 a.m.
Hosts: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director, and Gabriel Corfas, Associate Chair, Otolaryngology-Head and Neck Surgery, Professor of Otolaryngology-Head and Neck Surgery and Director, Kresge Hearing Research Institute, Medical School
 
Monday November 7
"Discovery of selective Orexin-2 antagonists for the treatment of Primary Insomnia"
Nicholas Carruthers, Ph.D., Senior Director/Neuroscience, Janssen
Life Sciences Institue Library, Room 3040
9 - 10 a.m.
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director
 
November 17
“For Scientists By Scientists: Case Studies in Eli Lilly’s Open Innovation Drug Discovery Platform”
Julia Marie Clay, Senior Research Scientist, Eli Lilly and Company
1 - 2 p.m.
Great Lakes, Palmer Commons
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

 

2015

December 11
Lori Isom, Ph.D., Chair, Department of Pharmacology and Jack Parent, M.D., Professor of Neurology, Medical School and Co-Director of U-M's Comprehensive Epilepsy Center
Use of patient-derived neurons and cardiac myocytes to study severe genetic epilepsies
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

December 3
Protein Folding Diseases Initiative Seminar
Vincent E. Groppi, Ph.D.
Center for the Discovery of New Medicines, Director
Leveraging the Resources of CDNM to Accelerate the Discovery of New Therapeutics to Treat Protein Folding Diseases
2515 BSRB
3 -  4:30 p.m.

November 20
Tomasz Cierpicki, Ph.D., and Jolanta Grembecka, Ph.D., University of Michigan
Assistant Professors of Pathology, Medical School
Drug discovery in academia: development of advanced pharmacological inhibitors of the menin-MLL interaction
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

November 13
Donna Huryn, Ph.D.
Research Professor at the University of Pittsburgh School of Pharmacy, and Adjunct Professor Department of Chemistry, University of Pennsylvania
Adventures in Academic Drug Discovery: from Acid Isosteres to Zebrafish
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

October 30
Michael Holinstat, Ph.D.
Associate Professor of Pharmacology and Internal Medicine and Director, Platelet Physiology and Pharmacology Core
Development of novel therapeutics in the platelet: New approaches to an old problem
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

October 16
Vernon Carruthers, Ph.D.
Associate Director, Cellular and Molecular Biology Program and Professor of Microbiology and Immunology, Medical School
New opportunities to abate the pervasive brain parasite Toxoplasma gondii
Host: Scott Larsen, Ph.D., Joseph Burckhalter Collegiate Research Professor, Director of the Vahlteich Medicinal Chemistry Core

October 7
Targets and Pathways probed by Structure and Screening: Celebrating a Decade of Discovery at the Life Sciences Institute Centers
Keynote by Mark Gurney, Ph.D., M.B.A., Chairman and CEO, Tetra Discovery Partners
Reinventing PDE-4D as a drug target for cognition based on the knowledge of its structure and function
8:30 a.m. to 1 p.m., includes breakfast, panel discussion, and lunch
More information

October 2
Kaushik Ghosal, Ph.D.
Business Development Manager
BioMotiv
Creative partnership to accelerate innovative medicine: Journey through valley of death
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

CANCELED DUE TO FAMILY EMERGENCY
September 25
Julia Clay, Ph.D.
Sr. Research Scientist, Open Innovation Drug Discovery, Discovery Chemistry
Eli Lilly and Company
For Scientists, By Scientists: Diverse models for collaboration
Host: Vincent E. Groppi, Ph.D., Center for the Discovery of New Medicines, Director

September 23
Yonghao Yu, Ph.D.
Assistant Professor of Biochemistry
University of Texas Southwestern Medical Center
New Advances in Large Scale Quantitative Proteomic Technologies and Associated Application in Cancer Research
BSRB, ABC Seminar Rooms
12 - 1 p.m.
Host: Jiandie Lin, Ph.D., Bradley M Patten Collegiate Professor in the Life Sciences

September 18
2nd Annual Protein Folding Diseases Initiative Symposium, Molecules and Machines
Speakers: Ulrich Hartl, Judith Frydman and Tom Rapoport
Location: Kahn Auditorium, Seminar Rooms A, B, and C, and the Upper Atrium in the A. Alfred Taubman Biomedical Science Research Building
9 a.m. - 5 p.m.

September 3
Hematology and Oncology Research Conference Lecture
Vincent E. Groppi, Ph.D.
Center for the Discovery of New Medicines, Director
Advancing Drug Discovery Projects from U-M's Strength in Basic and Clinical Research
Med Sci 1, M5330 Lecture hall
12 - 1 p.m.

August 28
Vincent E. Groppi, Ph.D.
Center for the Discovery of New Medicines, Director
Advancing Drug Discovery Projects from U-M's Strength in Basic and Clinical Research
Host: James Dalton, Ph.D., Dean and Professor of Pharmaceutical Sciences

April 24
Todd Herron, Ph.D. and José Jalife, M.D.
Research Assistant Professor, Molecular and Integrative Physiology and Research
Cyrus and Jane Farrehi Professor of Cardiovascular Research
Stem Cell-derived Cardiomyocyte Platform for Drug Testing and Discovery
Host: Vincent E. Groppi, Ph.D.

April 10
Derek J. Leishman
Senior Research Fellow, Head, Global PK/PD and Pharmacometrics
Eli Lilly and Company
The need and method for proarrhythmia assessment in drug discovery and development
Host: Vincent E. Groppi, Ph.D.

March 20
Melvin G McInnis, MD, FRCPsych
Thomas B and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression
Professor of Psychiatry
Mobile Technology Predicting Medical Outcomes
Host: Vincent E. Groppi, Ph.D.

March 13
Gabriel Corfas, Ph.D.
Professor and Associate Chair for Research, Department of Otolaryngology—Head and Neck Surgery
Director, Kresge Hearing Research Institute
Leveraging knowledge on the mechanisms of neuron-glia interactions to develop new therapies for peripheral neuropathy and hearing loss
Host: Vincent E. Groppi, Ph.D.

January 9
James A. Shayman, MD
Professor of Pharmacology and Internal Medicine
"Finding the sweet spot in treating Gaucher disease"
Host: Vincent E. Groppi, Ph.D.

2014

November 14
Peter Wipf, Ph.D.
University Professor of Chemistry
Department of Pharmacology & Chemical Biology at the University of Pittsburgh
"Therapeutic Opportunities of Chemical Targeting of Mitochondria"

October 3
David A. Casimir, J.D. Ph.D.
Patent, Trademark, Copyright Attorney
"Intellectual Property and Patents in Drug Development"

October 17
Robert H. Cichewicz, Ph.D.
Regents’ Professor and INPART Director
Department of Chemistry and Biochemistry, the University of Oklahoma
"The Massive Opportunities in the Minute World of Microbial Natural Products"


October 3
David A. Casimir, J.D. Ph.D.
Patent, Trademark, Copyright Attorney
"Intellectual Property and Patents in Drug Development"

June 13
Tomasz Cierpicki, P.h.D., Univeristy of Michigan
Assistant Professor of Pathology, Medical School
"Targeting challenging proteins using fragment-based approach"

May 23
Jolanta E. Grembecka, Ph.D., University of Michigan
Assistant Professor of Pathology, Medical School
"Development of potent inhibitors for protein-protein interactions: targeting the menin-MLL interaction in cancer"

May 2
Tom D. Hurley, Ph.D., Indiana University
Chancellor's Professor of Biochemistry and Molecular Biology
"Activation and Inhibition of Aldehyde Dehydrogenases: A random walk through a small molecule wilderness"

April 25
Judith S. Leopold, Ph.D., University of Michigan Health System
Research Associate Professor, Radiology, Medical School
"Design of Combination Therapies for Metastatic Colorectal Cancer:  Dual Targeting of MEK and CDK4/6"

April 18
Celebrate CDNM's Distinguished Lecture in Drug Discovery
           10 - 11:00  a.m.
           Dennis C. Liotta, Ph.D., D.Sc., Emory University
           Samuel Candler Dobbs Professor of Chemistry, The Emory Institute for Drug Development
           "Nucleoside Analogs as RNA-Dependent RNA Polymerase Inhibitors of Single Stranded RNA Viruses"
           Host: Shaomeng Wang, Ph.D.
           Location: 
Amphitheatre, 4th Floor, Rackham

           11:15 - 1:00
           Luncheon in Assembly Hall, 4th Floor, Rackham

           1:15 - 2:30
           Roundtable, East Conference Room, 4th Floor, Rackham

April 11
Zaneta Nikolovska-Coleska, Ph.D., University of Michigan
Associate Professor, Director of Molecular and Cellular Pathology Graduate Program
"Discovery and development of selective small molecule inhibitors of Mcl-1 as new cancer therapies"
Host: Shaomeng Wang, Ph.D.
Location: Forum Hall, Palmer Commons

March 28
Stephen Fesik, Ph.D., Vanderbilt University School of Medicine
Professor of Biochemistry, Pharmacology, and Chemistry & Orrin H. Ingram, II Chair in Cancer Research
"Discovery of Mcl-1 and Ras inhibitors for the treatment of cancer"
Host: Shaomeng Wang, Ph.D.
Location: Forum Hall, Palmer Commons

March 21
Zhong-Yin Zhang, Ph.D., Indiana University
Robert A. Harris Professor and Chair of Biochemistry and Molecular Biology
"Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases"
Host: Shaomeng Wang, Ph.D.
Location: Forum Hall, Palmer Commons

March 7
Roger K. Sunahara, Ph.D., University of Michigan
Professor of Pharmacology, University of Michigan Medical School
Receptor-G protein allostery and novel small molecule modulators
Host: Shaomeng Wang, Ph.D.
Location: Forum Hall, Palmer Commons

February 28
Yali Dou, Ph.D., University of Michigan
Associate Professor, Department of Pathology
"Targeting histone H3 K4 methyltransferase MLL1"
Host: 
Shaomeng Wang, Ph.D.
Location: Great Lakes Central, Palmer Commons

February 7
Diane M. Simeone, M.D., University of Michigan Health Systems
Lazar J. Greenfield Endowed Professor of Surgery and Molecular and Integrative Physiology and Director of the Translational Oncology Program
"The Translational Oncology Program (TOP)"
Host: Shaomeng Wang, Ph.D.
Location: Great Lakes North, Palmer Commons

January 31
Nouri Neamati, Ph.D., University of Michigan
John G. Searle Professor of Medicinal Chemistry, Department of Medicinal Chemistry and Translational Oncology Program
"Discovery of first-in-class and orally active PDI and gp130 inhibitors"
Host: Shaomeng Wang, Ph.D.
Location: Great Lakes South, Palmer Commons

January 17
Shaomeng Wang, Ph.D., University of Michigan
Warner-Lambert/Parke-Davis Professor of Medicine and Director of the Center for Discovery of New Medicines
"Making an impact in academic drug discovery: the path from discovery to clinical development"
Host: Alan R. Saltiel, PhD, Mary Sue Coleman Director of the Life Sciences Institute
Location: Forum Hall, Palmer Commons

2013

Dec. 13
Greg Thurber, The University of Michigan
"Structure Based Predictions of Drug Distribution"
Host:  Shaomeng Wang, Ph.D.

Dec. 6
Ronald Buckanovich, M.D., Ph.D., The University of Michigan Health System
"Developing Novel ALDH inhibitors to Target Cancer Stem Cells"
Host:  Scott Larsen, Ph.D.

Nov. 22
William Roush, Ph.D., The Scripps Research Institute
"Development of Proof-of -Concept Chemical Probes Targeting Novel Biological Targets"
Host:  Scott Larsen, Ph.D.

Nov. 8
Sheo Singh, Ph.D., Merck Research Laboratories
"Discovery and Development of Kibdelomycin"
Host:  David Sherman, Ph.D.
 
Oct. 25
Michael Pollastri, Ph.D., Northeastern University
"Expediting Drug Discovery for Neglected Tropical Diseases Using Target Repurposing"
Host:  Scott Larsen, Ph.D.
 
Oct. 11
Robert Zivin, Ph.D., University of Miami
"Success in Drug Discovery, Why Not Me?"
Host:  Martha Larsen

Sep. 13
Duxin Sun, Ph.D., The University of Michigan
"Disruption of protein-protein interactions in Hsp90 complex for cancer therapy"
Host:  Martha Larsen

June 14
Shannon Reilly, The University of Michigan, Life Science Institute
"Amlexanox, An Inhibitor of Non-Canonical IKKs, and Promising New Drug for the Treatment of Metabolic Disease" 
Host:  Martha Larsen

May 31
Anne Carpenter, Ph.D.,
"Extracting Rich Information From Biological Images To Tackle World Health Problems"
Host:  Martha Larsen

May 17
Mohamad Shebley, Ph.D., Abbott Laboratories
"A Novel Multi-Parametric Optimization to Enhance Success of Discovery Projects at AbbVie"
Host:  Richard R. Neubig, M.D., Ph.D.

April 26
Martin Michel, Ph.D., Boehringer Ingelheim Pharma
"The Do's and Don'ts  of Academia-Industry Relationships"
Host:  Richard R. Neubig, M.D., Ph.D.

April 19
Erin Carlson, Ph.D., Indiana University
"Chemical Probes to Explore and Inhibit Bacterial Pathogensis"
Host:  Anna Mapp

April 5
Robert Rottapel, Ph.D., University of Toronto
"Hacking the Source Code of Cancer:  Identification of an Essential Amplifying Loop in Ras Transformed Tumors"
Host:  Richard R. Neubig, M.D., Ph.D.

March 22
Mike Walters, MPh.D., University of Minnesota
Research Professor/Medicinal Chemistry
Director, Combinatorial Chemistry Laboratory for the Institute for Therapeutics Discovery & Development
"Now We are 6:  Lessons From Six years of drug R&D at the (other) U of M"
Host:  Scott Larson, Ph.D.

March 8
Rebecca Anthouard, the University of Michigan Medical School
"A Tale of Two Toxtazins:  Virulence Inhibitors of Vibrio cholerae"
Host:  Richard R. Neubig, M.D., Ph.D.

February 22
Timothy R. Hughes, Ph.D., University of Toronto
Professor, Banting and Best Department of Medical Research
Donnelly Centre for Cellular and Biomolecular Research
"Exploring the Eukaryotic Protein-Nucleic Acid Interactome"
Host: Jason Gestwicki, Ph.D.

February 8
Alejandra Yep, the University of Michigan Medical School
Assistant Research Scientist, Mobley Lab
"Small Molecule Inhibitors of Bacterial Iron Acquisition"
Host:  Richard R. Neubig, M.D., Ph.D.

January 25
Michael Jackson, Ph.D., Sanford Burnham Medical Research Institute 
V.P. Drug Discovery and Development
Conrad Prebys Center for Chemical Genomics (CPCCG)
"Drug Discovery in academia: Creating value in a mission-driven organization"
Host:  Tonia Buchholz, Ph.D.

January 11
Jorge Iniguez-Lluhi, Ph.D., the University of Michigan Medical School
Associate Professor, Department of Pharmacology
"The SUMOylation pathway as a therapeutic target in prostate cancer"
Host: Richard R. Neubig, M.D., Ph.D.

2012

Dec. 14
Michelle Arkin, Small Molecule Discovery Center, University of California, San Francisco
"Complementary discovery approaches for tackling challenging drug targets"
Host: Jason Gestwicki

Nov. 30
Shaomeng Wang, Ph.D, the University of Michigan
"Targeting protein-protein interactions for new cancer therapeutics: From Apoptosis to Epigenetics"

Host: Richard Neubig

Nov. 16
John Bushweller, University of Virginia
"Targeting Transcription Factors in Leukemia - A New Potential Paradigm for Treatment"
Hosts: Martha Larsen, Jolanta Grembecka and Tomek Cierpicki


Nov. 2
Adrian Whitty, Boston University
"Inhibiting Protein-Protein Interactions"
Host: Jason Gestwicki

Oct. 23, 2012
Christopher P. Austin, M.D.,  Director, National Center for Advancing Translational Sciences, NIH
"Translational Therapeutics Development at NIH"
Co-Hosts: Richard Neubig, CDNM and Thomas P. Shanley, MICHR